Natera

Natera Competitive Intelligence & Landscape

natera.com ·

Overview

Natera Overview

Natera (natera.com) is a global leader in cell-free DNA (cfDNA) testing, specializing in oncology, women's health, and organ health. The company's mission is to integrate personalized genetic testing and diagnostics into standard care to safeguard health and enable earlier, more precise interventions, ultimately leading to improved health outcomes and extended lives. Their advanced cfDNA technology platform merges molecular biology techniques with bioinformatics software and AI, allowing for the detection of even a single molecule in a blood sample. With over 20 years of experience, Natera has conducted more cfDNA tests than any other company.

Natera offers a comprehensive portfolio of genetic tests. In oncology, key products include Signatera™ for residual disease (MRD) testing, Latitude™ for tissue-free MRD, Altera™ for tumor genomic profiling, and Empower™ for hereditary cancer. For organ health, they provide Prospera™ for transplant assessment (kidney, heart, lung) and Renasight™ for kidney gene panels. Their women's health offerings feature Horizon™ for advanced carrier screening, Panorama™ for noninvasive prenatal testing (NIPT), Vistara™ for single-gene NIPT, and Anora™ for miscarriage testing. They also offer Zenith™ for rare disease genomics.

Natera primarily targets patients, clinicians, and biopharma partners, providing various services such as genetic information sessions, test kit orders, and EHR integration. The company has a significant presence in the genetic testing market, with their Panorama™ test being recognized as the most accurate non-invasive prenatal test. The company also provides support through resources like the NateraConnect Provider Portal and the Natera Patient Assistant.

Headquartered in San Carlos, CA, with an additional office in Austin, TX, Natera is powered by a team of over 3,000

Natera

Natera Weekly Intel Updates

Receive weekly intel updates about Natera straight to your inbox.

Competitors

Natera Competitors

Natera (natera.com) operates in a competitive landscape with several companies offering genetic testing and biotechnology solutions. One significant competitor is Exact Sciences (genomichealth.com), which focuses on cancer prevention, screening, and therapy guidance, notably with their multi-cancer early detection test, Cancerguard®. While Natera specializes in cell-free DNA testing across oncology, organ health, and women's health, Exact Sciences primarily centers on cancer, offering a more direct competitive overlap in oncology. Their differentiators lie in the specific types of tests and technologies offered, with Natera emphasizing advanced cell-free DNA for residual disease and transplant assessment, and Exact Sciences focusing on broader cancer detection.

Another key competitor for Natera is Guardant Health (GH), which, like Natera, is involved in liquid biopsy and precision oncology. While both companies offer tests for cancer patients, their market share and specific test offerings may vary.

Guardant Health is frequently compared with Natera in stock market analyses, indicating a direct rivalry in the investor community and the broader oncology diagnostics market. Pricing and feature comparisons would depend on specific test panels and services provided by each company.

Ambry Genetics and 23andMe are also listed as top competitors for Natera.

Ambry Genetics is known for its comprehensive genetic testing across various medical specialties, including hereditary cancer, cardiovascular, and neurological conditions, positioning it as a broader genetic testing provider.

23andMe, while initially recognized for its direct-to-consumer ancestry and health reports, has also ventured into therapeutic development and clinical applications, indirectly competing with Natera in the broader genetic information space, though their primary business models differ significantly.

Companies like Incyte and Vertex Pharmaceuticals are identified as main competitors for Natera in a broader sense within the biotechnology and pharmaceutical sectors. However, their primary business models and product offerings may differ significantly from Natera's focus on diagnostic testing. While Natera develops and commercializes genetic tests, companies like Incyte (zippia.com/natera-careers-7877/competitors/) and Vertex Pharmaceuticals (zippia.com/natera-careers-7877/competitors/) are more focused on drug discovery and development, making them more indirect competitors in the overall healthcare market rather than direct rivals in genetic diagnostics. For direct comparisons in terms of features and pricing, Natera's specific test panels would need to be evaluated against similar diagnostic services offered by these broader biotech firms, which is often not their primary focus.

Product & Pricing

Natera Product and Pricing Intelligence

Natera (natera.com) provides extensive cell-free DNA testing services across oncology, organ health, women's health, and rare diseases, with a strong emphasis on making their testing affordable and accessible through various billing programs and financial assistance options [natera.com]. The company prioritizes price transparency and offers support for patients to understand the costs associated with their tests.

For Women's Health tests like Panorama™, Horizon™, Empower™, and Vistara™, Natera offers a dedicated form to request a cost estimate, with a support team contacting individuals within several days of submission [natera.com/womens-health/pricing-billing/cost-estimate/]. The cost of Panorama™, a highly accurate prenatal screening test, varies, and Natera aims for transparency in billing for all its services [natera.com/womens-health/panorama-nipt-prenatal-screening/faq/].

In Organ Health, tests such as Prospera™ for transplant assessment and Renasight™ for kidney gene panels are covered by Medicare for select indications [natera.com/organ-health/prospera-organ-transplantation-assessment/faq/].

Natera welcomes all insurance plans, including Medicare, and provides prompt-pay cash prices and financial assistance options. Billing support is available via phone for any inquiries [natera.com/organ-health/organ-health-pricing-billing/].

For Oncology tests, including Signatera™ for residual disease and Altera™ for tumor genomic profiling, Natera also accepts self-pay pricing and offers financial assistance.

Signatera™, a personalized cancer management test, is covered by Medicare for specific indications [natera.com/oncology/signatera-advanced-cancer-detection/]. Billing support for oncology services is available by phone during business hours [natera.com/oncology/billing/].

Hiring & Layoffs

Natera Hiring and Layoffs

Natera has demonstrated a strong commitment to growth and expansion, particularly in its scientific and operational capabilities. The company recently announced a significant expansion of its operations in Austin, Texas, aiming to create up to 400 new jobs in professional, laboratory, and operational roles. This move signals Natera's strategic intent to bolster its position as a global leader in cell-free DNA testing across oncology, women's health, and organ health, by increasing its capacity for personalized genetic testing and diagnostics.

While Natera's main careers page invites prospective employees to view job openings and learn about benefits, an investor-focused careers page indicates there may not always be opportunities available, suggesting that hiring can be targeted rather than continuous across all departments. Despite this, the company's overall trajectory reflects a growing workforce, with Natera reporting 4.3K employees and a 28% year-over-year increase, indicating a positive hiring trend.

This expansion and consistent growth in employee numbers align with Natera's mission to integrate personalized genetic testing into standard healthcare practices. The focus on new roles in laboratory and operational functions, as well as professional positions, underscores Natera's dedication to enhancing its research, development, and delivery of advanced diagnostic solutions. The company's recognition on U.S. News & World Report's 2024 "Best Companies to Work For in Healthcare" ranking further highlights its commitment to attracting and retaining talent, supporting its strategic objectives in a competitive industry.

Leadership

Natera Management and Leadership Team

Natera's leadership team is headed by Steve Chapman, who serves as Chief Executive Officer and is also a member of the company's board of directors [natera.com/company/leadership-team/steve-chapman/]. Chapman is recognized as a leading authority in commercialization [natera.com/company/leadership-team/steve-chapman/]. He was appointed CEO on January 2, 2019, succeeding co-founder Matthew Rabinowitz, Ph.D. [investor.natera.com/news/news-details/2019/Natera-Appoints-Steve-Chapman-CEO-and-Robert-Schueren-COO-Matthew-Rabinowitz-Moves-to-Executive-Chairman/default.aspx].

Matthew Rabinowitz, Ph.D., a co-founder of Natera, transitioned from CEO (a role he held from 2005 to 2019) to Executive Chairman of the Board [investor.natera.com/governance/board-of-directors/person-details/default.aspx?ItemId=d1b5d085-49a4-49b2-b3e7-deaf01bb84e3]. In 2024, Rabinowitz was recognized as R&D Leader of the Year by R&D World [natera.com/company/news/natera-co-founder-and-executive-chairman-matthew-rabinowitz-named-2024-rd-leader-of-the-year/]. Another co-founder, Jonathan Sheena, has been a director on the board since 2007 and previously served as Chief Technology Officer from 2007 to December 2020 [investor.natera.com/governance/board-of-directors/person-details/default.aspx?ItemId=6da63729-8829-4f6c-a962-e2b90d9e3f14].

Recent leadership appointments at Natera include Solomon Moshkevich being promoted to President of Clinical Diagnostics. In this role, Moshkevich oversees the general managers for oncology, women's health, and organ health, and is also responsible for customer service, clinical trial operations, program management, and regulatory affairs [investor.natera.com/news/news-details/2023/Natera-Announces-Senior-Leadership-Appointments/default.aspx].

John Fesko serves as President & Chief Business Officer, having joined the company in 2014 and held various leadership positions [natera.com/company/news/natera-announces-senior-leadership-appointments/].

The medical leadership team includes Alexey Aleshin, MD, MBA, who serves as General Manager, Oncology and ECD, and Chief Medical Officer, alongside Minetta Liu, MD, who is the Chief Medical Officer for Oncology and ECD, and Sangeeta Bhorade [natera.com/company/medical-directors/]. These individuals contribute to Natera's focus as a global leader in cell-free DNA testing across its various health sectors [investor.natera.com/news/news-details/2023/Natera-Announces-Senior-Leadership-Appointments/default.aspx].

Financials

Natera Financial Performance, Fundraising, M&A

Natera (natera.com) has demonstrated robust financial growth, with a significant increase in total revenues across recent periods. For the full year 2025, the company reported total revenues of $2,306.1 million [source]. This represents a substantial increase from the full year 2024, which saw total revenues of $1,696.9 million [source].

The company's growth trajectory continued into 2026, with first-quarter revenues reaching $696.6 million, an increase of 38.8% compared to $501.8 million in the first quarter of 2025 [source]. Similarly, the fourth quarter of 2025 generated $665.5 million in total revenues, a 39.8% increase from $476.1 million in the fourth quarter of 2024 [source].

Natera also reported strong performance in the second quarter of 2025, with total revenues of $546.6 million, up 32.2% from $413.4 million in the second quarter of 2024 [source]. The company has consistently achieved positive cash inflow and maintained strong gross margins, indicating solid financial health. In the first quarter of 2026, Natera achieved a gross margin of 64.2%, up from 63.1% in the first quarter of 2025 [source].

Partnerships

Natera Partnerships, Clients and Vendors

Natera (natera.com) actively engages in strategic partnerships and integrations to expand its reach and enhance its precision medicine offerings. The company collaborates with biopharma services to accelerate clinical development, offering biomarker-guided trials, molecular insights, and access to unique patient populations [https://www.natera.com/oncology/signatera-advanced-cancer-detection/research-pipeline/pharma-partnerships/]. Notably, Natera has partnered with Exelixis, Inc. for the STELLAR-316 Phase 3 pivotal trial in colorectal cancer, utilizing Signatera™ for patient identification and therapy monitoring [https://www.natera.com/company/news/exelixis-and-natera-to-collaborate-on-stellar-316-a-phase-3-pivotal-trial-of-zanzalintinib-for-patients-with-colorectal-cancer/]. Other key biopharma collaborations include CytoDyn Inc. to evaluate ctDNA dynamics in metastatic colorectal cancer [https://www.natera.com/company/news/natera-and-cytodyn-announce-strategic-collaboration-to-advance-ctdna-guided-development-and-molecular-response-analysis-in-metastatic-colorectal-cancer/], Aveta Biomics for a global Phase 3 trial in head and neck cancer [https://www.natera.com/company/news/natera-and-aveta-biomics-announce-strategic-partnership-supporting-global-phase-3-registrational-trial-of-apg-157-in-head-and-neck-cancer/], and Eledon for Prospera™ monitoring in a planned Phase 3 kidney transplant trial [https://www.natera.com/company/news/natera-and-eledon-announce-strategic-partnership-for-prospera-monitoring-in-planned-phase-3-kidney-transplant-trial/].

Natera also focuses on integrating its genomic tests into healthcare systems to improve patient outcomes and standardize care [https://www.natera.com/health-systems/]. The company integrates with all major EHR systems, ensuring test results flow directly into patient records to facilitate care decisions [https://www.natera.com/ehr/]. A significant integration is with Flatiron Health’s OncoEMR® Platform, which provides streamlined electronic access to Natera’s clinical oncology portfolio for over 4,500 cancer care providers within Flatiron Health's network [https://www.natera.com/company/news/natera-integrates-with-flatiron-healths-oncoemr-platform/]. This partnership underscores Natera's commitment to enhancing accessibility and workflow for clinicians.

Furthermore, Natera is advancing its technological capabilities through collaborations aimed at scaling AI foundation models in precision medicine. A notable partnership is with NVIDIA, where Natera integrates its unique longitudinal and multi-time point in vivo datasets and proprietary machine learning models with NVIDIA’s high-performance computing platform to expand AI applications across precision medicine [https://www.natera.com/company/news/natera-to-scale-ai-foundation-models-in-precision-medicine-with-nvidia/]. These strategic alliances highlight Natera's dedication to innovation and broader adoption of its advanced cell-free DNA testing technologies.

Events

Natera Event Participations

Natera actively participates in a variety of events, including conferences, webinars, and investor calls, to share advancements in cell-free DNA testing and precision medicine. They maintain an events page on their website where users can filter by event type, such as "Event" or "Webinar," and by topics like Oncology, Organ Health, and Women's Health tests and services [https://www.natera.com/events/].

The company is a regular presence at significant healthcare conferences. For instance, Natera announced its participation in the 44th Annual J.P. Morgan Healthcare Conference, held on January 13, 2026, where management delivered a presentation [https://www.natera.com/company/news/natera-to-participate-in-the-44th-annual-j-p-morgan-healthcare-conference/][https://investor.natera.com/events-and-presentations/events/event-details/2026/44th-Annual-JP-Morgan-Healthcare-Conference-2026-8khCChg0K_/default.aspx]. They also plan to attend the Goldman Sachs 47th Annual Global Healthcare Conference on June 8, 2026 [https://investor.natera.com/events-and-presentations/events/default.aspx].

Natera frequently presents new research and data at major medical meetings. They announced a landmark oncology data program for the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, scheduled from May 29–June 2, where they planned to present 35 studies [https://www.natera.com/company/news/natera-to-present-35-studies-at-asco-extending-clinical-data-leadership-in-oncology/].

In addition to in-person conferences, Natera hosts and participates in webinars to disseminate information. Examples include a webinar on March 17, 2026, discussing new EXPAND & VANISH data presented at SMFM 2026 [https://info.natera.com/EXPAND-and-SMFM-Recap-Reg-Page]. Another webinar series, "Driving Precision in Breast Cancer Care," included a session on October 16, 2025, focused on optimizing breast cancer surveillance with MRD testing [https://info.natera.com/Breast-Cancer-Surveillance-Registration-Page]. The company also conducts quarterly earnings conference calls, such as the Q1 Earnings Conference Call on May 7, 2026, and the Q4 Earnings Conference Call on February 26, 2026 [https://investor.natera.com/events-and-presentations/events/default.aspx][https://investor.natera.com/events-and-presentations/events/event-details/2026/Natera-Inc-Q4-Earnings-Conference-Call/default.aspx].

Frequently Asked Questions

What is Natera's strategic focus for growth, based on its recent hiring initiatives?

Natera is strategically focused on expanding its scientific and operational capabilities to solidify its leadership in cell-free DNA testing. This is evidenced by a significant expansion in Austin, Texas, aiming to create up to 400 new jobs in professional, laboratory, and operational roles, which will increase capacity for personalized genetic testing across oncology, women's health, and organ health.

How do Natera's recent financial results indicate its market position and growth trajectory?

Natera's robust financial growth, with full year 2025 revenues reaching $2,306.1 million, up from $1,696.9 million in 2024, indicates a strong market position and positive growth trajectory. Consistent increases in quarterly revenues, such as a 38.8% rise in Q1 2026, and strong gross margins (64.2% in Q1 2026) demonstrate solid financial health and increasing demand for its cell-free DNA testing services.

What does Natera's participation in key industry conferences suggest about its strategy for market influence?

Natera's consistent participation in key industry conferences, such as the J.P. Morgan Healthcare Conference, Goldman Sachs Global Healthcare Conference, and ASCO Annual Meeting, indicates a strategy to maintain and extend its market influence. By presenting significant research, like 35 studies at ASCO 2026, Natera aims to showcase advancements in cell-free DNA testing and reinforce its leadership in precision medicine.

What is the strategic significance of Natera's partnerships with biopharma companies for its oncology pipeline?

Natera's partnerships with biopharma companies like Exelixis, Inc., CytoDyn Inc., and Aveta Biomics are strategically significant for accelerating its oncology pipeline. These collaborations utilize Natera's Signatera™ for patient identification and therapy monitoring in pivotal trials, demonstrating its role in biomarker-guided clinical development and expanding the application of its precision oncology solutions.

How does Natera's integration with EHR systems and Flatiron Health impact its market accessibility for clinicians?

Natera's integration with all major EHR systems and specifically with Flatiron Health’s OncoEMR® Platform significantly enhances its market accessibility for clinicians. This allows test results to flow directly into patient records and provides streamlined electronic access to Natera's oncology portfolio for over 4,500 cancer care providers, simplifying workflow and facilitating care decisions.

What role does Natera's co-founder Matthew Rabinowitz play in the company's long-term strategic direction?

Matthew Rabinowitz, Natera's co-founder and former CEO, transitioned to Executive Chairman of the Board, indicating his continued influence on the company's long-term strategic direction. His recognition as R&D Leader of the Year in 2024 suggests a sustained focus on innovation and research, which aligns with Natera's mission as a leader in cell-free DNA testing.

How does Natera's product portfolio for women's health tests differentiate itself in the market?

Natera's women's health product portfolio, including Panorama™ for NIPT, Horizon™ for carrier screening, and Vistara™ for single-gene NIPT, differentiates itself through advanced cell-free DNA technology and claimed accuracy. Panorama™ is specifically recognized as the most accurate non-invasive prenatal test, emphasizing a commitment to precise diagnostic solutions.

In what specific areas does Exact Sciences pose a direct competitive threat to Natera?

Exact Sciences poses a direct competitive threat to Natera primarily in the oncology space. Both companies offer tests for cancer detection and management, with Exact Sciences focusing on cancer prevention, screening, and therapy guidance, including multi-cancer early detection, which directly overlaps with Natera's oncology tests like Signatera™ and Altera™.

What is Natera's strategy for making its genetic testing services financially accessible to patients?

Natera's strategy for financial accessibility includes various billing programs, financial assistance options, and price transparency initiatives. They accept all insurance plans, including Medicare for select indications, offer prompt-pay cash prices, and provide dedicated support teams for cost estimates and billing inquiries across their women's health, organ health, and oncology services.

How is Natera leveraging AI and high-performance computing to advance its precision medicine capabilities?

Natera is leveraging AI and high-performance computing through a partnership with NVIDIA. This collaboration integrates Natera's unique longitudinal and multi-time point in vivo datasets and proprietary machine learning models with NVIDIA’s platform to scale AI foundation models, expanding AI applications across precision medicine and enhancing its diagnostic capabilities.

What does Natera's expansion of operations in Austin, Texas, signal about its future strategic priorities?

Natera's expansion of operations in Austin, Texas, with plans for up to 400 new jobs, signals a strategic priority to significantly increase its capacity for personalized genetic testing. This move is aimed at bolstering its position as a global leader in cell-free DNA testing across oncology, women's health, and organ health, by enhancing research, development, and diagnostic delivery.

Powered by ForesightIQ · Competitive intelligence from digital exhaust